Tirosint: Indications, Side Effects, Warnings - Drugs.com (2024)

Generic name: Levothyroxine Capsules [lee-voe-thye-ROKS-een]
Drug class: Thyroid drugs

Medically reviewed by Drugs.com. Last updated on Apr 25, 2024.


  • Do not use Tirosint (levothyroxine capsules) to treat obesity or for weight loss. Very bad and sometimes deadly side effects may happen with Tirosint (levothyroxine capsules) if it is taken in large doses or with other drugs for weight loss. Talk with the doctor.

Uses of Tirosint:

  • It is used to add thyroid hormone to the body.
  • It is used to manage thyroid cancer.
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take Tirosint?

  • If you have an allergy to levothyroxine or any other part of Tirosint (levothyroxine capsules).
  • If you are allergic to Tirosint (levothyroxine capsules); any part of Tirosint (levothyroxine capsules); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you have any of these health problems: Overactive thyroid gland or weak adrenal gland.
  • If you have trouble swallowing.

This is not a list of all drugs or health problems that interact with Tirosint (levothyroxine capsules).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Tirosint (levothyroxine capsules) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Tirosint?

For all patients taking Tirosint (levothyroxine capsules):

  • Tell all of your health care providers that you take Tirosint (levothyroxine capsules). This includes your doctors, nurses, pharmacists, and dentists.
  • Do not run out of Tirosint (levothyroxine capsules).
  • It may take several weeks to see the full effects.
  • If you have high blood sugar (diabetes), Tirosint (levothyroxine capsules) may sometimes raise blood sugar. Talk with your doctor about how to keep your blood sugar under control.
  • Check your blood sugar as you have been told by your doctor.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • This medicine may cause weak bones (osteoporosis) with doses that are too high. The risk may be higher in women who have been through menopause. Talk with your doctor to see if you have a higher risk of weak bones or if you have any questions.
  • This medicine may affect fertility. Fertility problems may lead to not being able to get pregnant or father a child.
  • If you are 65 or older, use Tirosint (levothyroxine capsules) with care. You could have more side effects.
  • Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.


  • If giving Tirosint (levothyroxine capsules) to your child and your child's weight changes, talk with the doctor. The dose of Tirosint (levothyroxine capsules) may need to be changed.
  • This medicine may affect growth in children and teens in some cases. They may need regular growth checks. Talk with the doctor.

How is this medicine (Tirosint) best taken?

Use Tirosint (levothyroxine capsules) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take on an empty stomach at least 30 to 60 minutes before breakfast.
  • Swallow capsule whole. Do not chew, break, or crush.
  • Do not take iron products, antacids that have aluminum or magnesium, or calcium carbonate, within 4 hours before or 4 hours after taking Tirosint (levothyroxine capsules).
  • If you take colesevelam, colestipol, cholestyramine, kayexalate, or sevelamer, take it at least 4 hours before or 4 hours after taking this drug.
  • Some other drugs may need to be taken at some other time than Tirosint (levothyroxine capsules). If you take other drugs, check with your doctor or pharmacist to see if you need to take them at some other time than Tirosint (levothyroxine capsules).
  • Some foods like soybean flour (infant formula) may change how Tirosint (levothyroxine capsules) works in your body. Talk with your doctor.
  • If you drink grapefruit juice or eat grapefruit often, talk with your doctor.
  • There is more than 1 brand of Tirosint (levothyroxine capsules). One brand cannot safely be used for the other. The doctor will tell you about any needed change.
  • Keep taking Tirosint (levothyroxine capsules) as you have been told by your doctor or other health care provider, even if you feel well.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

Detailed Tirosint dosage information

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
  • Chest pain or pressure.
  • Fast or abnormal heartbeat.
  • Shortness of breath, a big weight gain, or swelling in the arms or legs.
  • Headache.
  • Feeling tired or weak.
  • Feeling more or less hungry.
  • A change in weight without trying.
  • Diarrhea.
  • Stomach cramps.
  • Throwing up.
  • Feeling irritable.
  • Feeling nervous and excitable.
  • Anxiety.
  • Emotional ups and downs.
  • Shakiness.
  • Trouble sleeping.
  • Bothered by heat.
  • Sweating a lot.
  • Fever.
  • Muscle cramps.
  • Muscle weakness.
  • Flushing.
  • Bone pain.
  • Period (menstrual) changes.

Tirosint side effects (more detail)

What are some other side effects of Tirosint?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Hair loss may happen in some people in the first few months of using Tirosint (levothyroxine capsules). This most often goes back to normal.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Tirosint?

  • Store at room temperature.
  • Protect from heat and light.
  • Store in a dry place. Do not store in a bathroom.
  • Do not take Tirosint (levothyroxine capsules) out of the blister pack until you are ready to take it. Take Tirosint (levothyroxine capsules) right away after opening the blister pack. Do not store the removed drug for future use.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer Information Use and Disclaimer

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Tirosint (levothyroxine capsules), please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Frequently asked questions

  • Should you take your thyroid medication at night?
  • Can Tirosint cause weight gain or loss?
  • How long does Tirosint stay in your system?
  • Is Tirosint gluten-free?
  • Does levothyroxine cause weight gain or loss?
  • What can I eat for breakfast after taking levothyroxine?
  • Can I take other medications with levothyroxine?
  • Does levothyroxine cause hair loss?
  • How long after taking levothyroxine can you drink milk?

View more FAQ

More about Tirosint (levothyroxine)

  • Check interactions
  • Compare alternatives
  • Reviews (138)
  • Drug images
  • Latest FDA alerts (1)
  • Side effects
  • Dosage information
  • During pregnancy
  • Drug class: thyroid drugs
  • Breastfeeding
  • En español

Patient resources

  • Tirosint advanced reading

Other brands

Synthroid, Euthyrox, Levoxyl, Unithroid, ... +3 more

Professional resources

  • Tirosint prescribing information
  • Levothyroxine (AHFS Monograph)

Other brands

Synthroid, Euthyrox, Levoxyl, Unithroid, ... +5 more

Related treatment guides

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  • Hypothyroidism, After Thyroid Removal
  • Myxedema Coma
  • TSH Suppression
  • Thyroid Suppression Test
  • Underactive Thyroid

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circ*mstances.

Medical Disclaimer

Tirosint: Indications, Side Effects, Warnings - Drugs.com (2024)


What are the indications for Tirosint? ›

TIROSINT is indicated as a replacement therapy in adults and pediatric patients 6 years and older with primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) congenital or acquired hypothyroidism.

Does Tirosint have any side effects? ›

Side Effects for Tirosint

They include the following: General: fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating. Central nervous system: headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia. Musculoskeletal: tremors, muscle weakness, muscle spasm.

Does Tirosint make you gain weight? ›

Levothyroxine does not directly cause weight gain, though it may increase your appetite. Still, it may be more likely to cause weight loss as it restores your thyroid function and metabolism.

What to avoid when taking Tirosint? ›

7.9 Drug-Food Interactions Consumption of certain foods may affect TIROSINT absorption thereby necessitating adjustments in dosing [see Dosage and Administration (2.1)]. Soybean flour (infant formula), cottonseed meal, walnuts, and dietary fiber may bind and decrease the absorption of TIROSINT from the GI tract.

Why is Tirosint being recalled? ›

On March 1, 2023, the U.S. Food and Drug Administration (FDA) announced that IBSA Pharma Inc. is voluntarily recalling 27 lots of TIROSINT®-SOL (levothyroxine sodium) Oral Solution as a Class I Recall due to the medicine not being strong enough.

Is Tirosint better than levothyroxine? ›

For some patients this means that Tirosint may offer more consistent control of hypothyroid symptoms than similar doses of levothyroxine tablets. Simply stated, Tirosint does not contain excipients that can interfere with how well your body absorbs your thyroid medication, which ultimately can affect how well you feel.

What is the safest thyroid medication? ›

Experts consider levothyroxine to be the first-choice medication for treating hypothyroidism. This is because it works well and doesn't have too many side effects. Levothyroxine is generally preferred over medications like Armour Thyroid.

What vitamins interfere with Tirosint? ›

Products which can affect your thyroid medication
Calcium supplementsOsteoporosis, hypocalcemia
Iron supplementAnemia
Chromium picolinateNutritional supplement
Tagamet, Zantac**GERD, gastritis
5 more rows

Does Tirosint cause hair loss? ›

You may experience partial hair loss in the first few months of treatment, but this usually resolves and hair growth goes back to normal within a short time.

Can thyroid cause belly fat? ›

Even mild cases of hypothyroidism may increase the risk of weight gain and obesity. People with the condition often report having a puffy face as well as excess weight around the stomach or other areas of the body.

What does a thyroid belly look like? ›

A hormonal belly typically appears as accumulated fat around your waist, typically towards your lower waist. There are a few tell-tale signs that this excess weight is due to hormonal causes: You're only gaining weight around your abdomen.

Does Tirosint cause heart problems? ›

Overtreatment with this drug may cause an increase in heart rate, cardiac wall thickness, and cardiac contractility and may precipitate angina or arrhythmias, particularly in patients with cardiovascular disease and in elderly patients.

Can I drink coffee with Tirosint? ›

Coffee does not interfere with Tirosint. The medication is safe for people who have absorption problems, digestive issues, and allergies.

What are the symptoms of too much Tirosint? ›

US residents can call 1-800-222-1222. Canada residents can call 1-844-764-7669. Symptoms of overdose may include: fast/pounding/irregular heartbeat, loss of consciousness, confusion, seizures. Lab and/or medical tests (such as thyroid function) should be done while you are taking this medication.

What happens when you stop taking Tirosint? ›

If you suddenly stop your thyroid medication, you may be at risk of potentially serious symptoms, including: Blood pressure changes. Fatigue, muscle weakness or joint pain. Depression.

Is Tirosint a t3 or T4 medication? ›

Popular brand names for levothyroxine (T4) include but are not limited to Synthroid®, Levoxyl®, Unithyroid®, Tirosint® in the United States and Euthyrox® and Eltroxin® in Europe.

What are other indications for levothyroxine? ›

Levothyroxine is used to treat hypothyroidism (condition where the thyroid gland does not produce enough thyroid hormone). It is also used with surgery and radioactive iodine therapy to treat thyroid cancer. Levothyroxine is in a class of medications called hormones.

When should I take Tirosint? ›

Take this medication by mouth as directed by your doctor, usually once daily on an empty stomach, 30 minutes to 1 hour before breakfast. Some brands may also be taken 15 minutes before breakfast. Ask your pharmacist about your brand of levothyroxine.

What is Synthroid indication and use? ›

SYNTHROID® (levothyroxine sodium) tablets, for oral use is a prescription, man-made thyroid hormone that is used to treat a condition called hypothyroidism in adults and children, including infants. It is meant to replace a hormone that is usually made by your thyroid gland.

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